Autism spectrum disorders (ASDs) are characterized by abnormalities in language and social behavior development. A new study stemming from a study done by researchers at the University of California, San Diego School of Medicine indicates that a majority of causes for autism are caused by a sustained cell danger response.
This suggests that autism happens when cells get fastened in a defensive metabolic mode and fail to communicate together, which can interfere with brain function and development. This theory was tested using a class of drugs that have been around for almost a century, to block the danger signal in a mouse model. They called this new treatment APT or antipurinergic therapy. A well known inhibitor, Suramin, most commonly used in African sleeping sickness treatment was tested. They found that in the mice model the drug restored 17 types of multi-symptom abnormalities, even after onset of symptoms.
The conclusions of this research, has given hope to an opportunity to develop a new class of anti-inflammatory drugs to treat autism spectrum disorders, as well as a small clinical trial in children with autism in the next year